The cytokines of the IL-12 family exhibit structural similarity, but have different functions in the immune system. There is relatively in-depth research on pro-inflammatory cytokines IL-12 and IL-23. These two cytokines share the cytokine subunit p40 and receptor β Chains, however, have different functions in autoimmune diseases, cancer, and infections.
Interleukin-12 (IL-12) is produced by activated antigen presenting cells (dendritic cells, macrophages). It promotes the development of Th1 response, causing T cells and NK cells to produce IFN γ A powerful inducer.
IL-12 mediated signal transduction
IL-12 and IL-23 activate the Jak/STAT pathway. IL-12 is composed of IL-12p40 and p35 subunits that bind to IL-12Rb1 and b2, respectively. Ligand binding causes the receptor chain to closely approach the associated Jaks (Jak2 and Tyk2), leading to Jak phosphorylation and subsequent activation of the Jaks phosphorylation receptor chain. IL-12Rb2 is phosphorylated and acts as a docking site for STAT4. STAT4 binds to the receptor chain and is self phosphorylated. The STAT4 homodimer shuttles into the nucleus and binds to the STAT binding site in the interferon (IFN) - g promoter, inducing transcription of the IFN-g gene through an unclear mechanism.
Chaselection IL-12 has high purity and excellent activity, making it a powerful assistant in your scientific research!
Higher purity: SEC-HPLC detection results, protein purity ≥ 95%
Higher activity: ≥ 2 * 107 units/mg
